An ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or dental lamina. It may be either. Ameloblastic fibroma, is a mixed odontogenic tumor, which commonly affects young children under the age of 20 years, with the mandibular premolar-molar. ameloblastic fibroma in a 9-year-old boy has been presented along with a review of the literature. The tumor responded to conservative surgical treatment.

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Microscopically the epithelial component occupies the mesenchymal stroma in various patterns like thin long strands, cords, nests, or islands.

A capsule is generally not appreciated. Int J Amelooblastic Health Sci ;4: In the present report, the presence of thin septa producing a stepladder pattern resembled that observed in myxoma, although odontogenic myxoma occurs most commonly in patients during third and fourth decades of life Ameloblastuc contrast to current case, the presence of epithelial islands is an infrequent finding in odontogenic myxoma The present case reports signifies the importance of careful differential diagnosis of intrabony oral lesions with an atypical location.

Larger nests may show a central area of stellate reticulum. As the lesion was well circumscribed, under local anesthesia, the patient was submitted to excision of the lesion. There were no carious or periodontal lesions in the left mandibular teeth. However, the diagnosis of malignant transformation is only established from the retrieval of the primary tumor or recurring tumors in which the original histological features of the AF can be observed 1.

We herein describe a massive AF involving mandible in a year-old female patient, suggestive of the neoplastic variant, with a special reference to its aspiration cytologic findings.

Ameloblastic fibroma

The peripheral epithelial cells lining the islands and strands were low columnar, similar to the cells found in the peripheral layer of the follicle in ameloblastoma. Ameloblastic fibroma and related lesions: A review of published studies with special reference to its nature and biological behavior. The present patient was only 2 years old, fitting into the normal spectrum of ameloblastic fibroma, with the youngest age reported in a seven-week-old infant [ 19 ].


How to cite this URL: However, large tumors or cases with multiple recurrences may require more extensive resections 1.

Ameloblastic Fibroma

The overlying mucosa was intact. In addition, orthodontic treatment was initiated Fig. Reported cases of ameloblastic fibromas with aspiration cytologic findings Click here to view. The surgical specimen was then sent for histopathological analysis.

As it is difficult to differentiate a hamartomatous lesion from a neoplasm based merely on histology, age of the patient should be an important consideration while deciding the treatment plan. Thus, the diagnosis fibrom AF was established. Several spindle-shaped cells and abundant extracellular amelpblastic deposition were found between the islands of neoplastic cells HE, x The diagnosis of AF was established.

The radiopaque portion was restricted to the peripheral area of the lesion. Hyaline-like tissue is also seen adjacent to the epithelial strands and islands [ Figure 2 ]. No tumor recurred up to 30 months after treatment. Footnotes Source of Support: World Health Organization Classification of Tumours: National Fibrroma for Biotechnology InformationU.

Ameloblastic fibroma is a rare odontogenic tumor comprising neoplastic epithelial and mesenchymal tissues. Ameloblastic fibroma is a true-mixed neoplasm of odontogenic origin with both epithelial and mesenchymal tissues [ 4 ].

Radiographically, AF appears as a well-defined, unilocular or multilocular radiolucent lesion, with sclerotic radiopaque margins ribroma4.

Ameloblastic fibroma, ameloblastic fibro-odontoma, and odontoma. Particularly in this case, mixed radiographic lesions, such as ossifying fibroma, extra-follicular variant of ameloblastuc odontogenic tumor, calcifying cystic odontogenic tumor and calcifying epithelial odontogenic tumor were also considered as hypotheses of diagnosis 12 – The authors declare that there is no conflict of interests regarding the publication of this paper.

Round islands and narrow cords of odontogenic epithelium in a cellular, primitive mesenchymal background.

Ameloblastic fibroma

However, the presence of ulceration and pain does not exclude the diagnosis of AF, as these symptoms have been reported in an extensive review carried out by Chen et al. Ameloblastic fibromas are neoplasms of odontogenic epithelium and mesenchymal tissues, and as such cibroma categorized as mixed odontogenic tumors.


Discussion AF predominantly affects young patients, with a mean age of 15 years 2 – 4. No atypia was observed. The medical history revealed no prior trauma or episodes of pain in the affected region. Benign Tumors of the Jaws.

Ameloblastic fibroma – Wikipedia

The ectomesenchymal component is composed of typical plump fibroblasts with delicate collagen fibrils simulating the dental papilla [ 24 ]. Malignant transformation of ameloblastic fibroma to ameloblastic fibrosarcoma: Ameloblastic fibromas AFs are a rare variety of benign odontogenic tumors composed of proliferating odontogenic epithelium embedded in a cellular ectomesenchymal tissue resembling dental papilla [ 1 ].

Herein, we report the first case of a bilateral maxillary ameloglastic fibroma in a 2-year-old female child patient who presented with a chief complaint of swelling in the right mid facial region. Radiographic Features Imaging studies revealed a well-circumscribed, unilocular radiolucency preventing eruption of the left maxillary second molar and displacing it in a superior and posterior direction, into the maxillary sinus Fig.

Text book of oral and maxillofacial pathology; pp. Introduction Ameloblastic fibromas AFs are a rare variety of benign odontogenic tumors composed of proliferating odontogenic epithelium embedded in a cellular ectomesenchymal tissue resembling dental papilla [ 1 ].

Ameloblastoma, odontogenic myxoma, keratocystic odontogenic tumor and central giant cell lesion should be considered in the differential ameloblaatic 39. Other clinical and radiographic clues are used to narrow the diagnosis. An year-old male presented for a routine dental examination with an incidental finding in the left posterior maxilla. This controversy further attributes to the difficulties to differentiate between the histology of the neoplastic and the hamartomatous lesions with the histologic features of ameloblastic fibroma [ 4 ].

Glandular and epithelial neoplasms ICD-O